Department of transplantology and experimental modeling with an experimental biological clinic

+38-057-725-14-38, +38-057-725-14-46

Department of transplantology and experimental modeling with an experimental biological clinic:

Vorontsov Petr
Head, PhD in Medicine (traumatology and orthopedics)
Nikolchenko Olga
Senior researcher, PhD in Biology (cytology, cell biology and histology), biologist
Ivanov Gennadiy
Researcher, biologist (biochemistry)
Poshelok Denis
Researcher, PhD in Biology (cryobiology), veterinarian
Velyaminova Viktoriya
Junior researcher, biologist (cytology)
Samoilova Kateryna
Junior researcher, ecologist
Sereda Olena
Junior researcher, laboratory physician
Orlenko Anton
Junior researcher, veterinarian
Grechishnikova Svetlana
Laboratory assistant 2nd category, veterinarian
Karnaukh Olga
Laboratory assistant, veterinarian
Lysenko Natalia
Animal care worker
Gorban Victoria
Animal care worker
Yatkina Liudmyla
Animal care worker

Department of transplantology of the musculoskeletal system:

Vorontsov Petr
Head, PhD in Medicine (traumatology and orthopedics)
Slota Oksana
Biologist (cytology)
Gusak Valerija
Laboratory physician
Sbitneva Inna
Economist
Maiboroda Alona
Laboratory assistant
Chersunova Ludmila
Laboratory assistant
Dolzhikova Olga
Junior nurse

Clinical fields:

  • Development of manufacturing technologies for bone allo- and xenogenic implants as well as bioengineering designs based on bone matrix combined with stem cells, drugs, platelet-rich plasma or fibrin (PRP or PRF)
  • Clinical implementation of the developed bone bioimplants of various shapes as osteoplastic materials for replacement of bone defects; study of their interactions with the patient’s body

 

Clinical achievements:

We offer dehydrated allogenic bone materials for clinical use: volumetric bone implants «OMS–A–VBI»®, cortico-cancellous particles «OMS–A–CCP»® (5-10 mm), bone powder-crumb «OMS–A– BPC»® (0.5-2.0 mm). These implant biomaterials are packaged and sterilized by radiation (patents No. 119699 UA, No. 119700 UA, certificate of conformity No. UA. TR. 101-21-2016).

In addition, allogenic bone materials can be denaturalized (i.e. extraction of the cells and of more organic components) and demineralized (i.e. extraction of the inorganic components). Our implant biomaterials can be used as a matrix for tissue-engineering designs in combination with drugs, patient’s platelet-rich plasma or fibrin (i.e. PRP or PRF), stem cells to replace damaged bone and optimize osteoreparative process in patients after osteoplastic surgery.

Scientific fields:

  • Development of new and introduction of known experimental animal models (rats, rabbits) in order to study in vivo the effects of drugs and physiotherapeutic agents, unhealthy exo- and endogenous factors on the musculoskeletal system under various pathologies
  • Experimental testing in vivo on animals (rats, rabbits) to carry out biological evaluation of medical devices (various implant and graft) and to study the course of reparative processes
  • Experimental in vitro studies of the effects of various drugs and physiotherapy factors on cultured cells (fibroblasts, chondroblasts, osteoblasts, bone marrow stromal cells); testing in vitro of new implant materials for its cytotoxicity and biocompatibility

 

Scientific achievements:

About 50 animal models have been developed to study the pathogenesis of various musculoskeletal diseases and the course of reparative processes, including models of osteoarthrosis, osteoporosis, osteochondrosis, scoliosis, intervertebral disc disorders, damage to vertebrae and long bones, etc.

The department performs in vivo and in vitro bioassays of new medical materials and designs, carries out morphometric measurements (somatometry, organometry, osteometry) to quantify the structural changes that occur in the animal body and organs after modeling various pathologies and effect of the studied factors (Certificates of conformity of the measurement system to the requirements of DSTU ISO 10012:2005 «Measurement management system. Requirements for measurement processes and measuring equipment», No. 01-0019/2019 and No. 01-0020/2019 from 2019.02.08).

Experimental biological clinic is equipped with the operating and X-ray rooms. There are 3 veterinarians in the department staff; they provide a skilled level of the experimental studies. The experimental process is organized in accordance with the requirements of the European convention for the protection of vertebrate animals used for experimental and other scientific purposes (Strasbourg, 1986), «Good Laboratory Practice» (SТ-G МHU 42-6.0: 2008), national standard DSTU ISO 10993 «Biological evaluation of medical devices». Certified equipment and compliance with international standards ISO 13485-2005, ISO 9001-2009 allow the department to work in the fundamental and clinical directions with bone allogenic implants and stem cell cultures (according to CMU Resolution No. 695 from 2000.04.24).

The department scientific and practical activities are associated with all departments of the Sytenko Institute as well as with other domestic and foreign institutes, universities and clinics (including researches supported by STCU grants – projects # 3174, # 4231).

The department published 6 monographs, 25 patents for invention, 165 articles, 2 methodical recommendations, 15 innovations during the past 20 years.

HEAD OF THE DEPARTMENT

PhD Vorontsov Petr

PhD
Vorontsov Petr

Photos

Колектив відділення трансплантології системи опори та руху: к.м.н. Воронцов П.М., Сбітнєва І.В., Сльота О.М., Гусак В.С.
Дегідратовані алокісткові об’ємні імплантати «ОМС-А- ОКІ» ®
Дегідратовані алокісткові кортико-губчастий гранулят «ОМС-А- КГГ» ® та порошок-крихта «ОМС-А- КПК»
Демінералізований кістковий матрикс. Сироватка крові, отримана для насичення кісткових алоімплантатів
Проведення експериментів in vivo з використанням лабораторних тварин (зав. відділом к.мед.н. Воронцов П.М., с.н.с., к.б.н. Нікольченко О.А., н.с. Іванов Г.В., ветеринарні лікарі Гречишніковою С.Б., Карнаух О.В.)
Cертифікати та Cвідоцтва
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