Scientific Activities | Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine

State Institution “Sytenko Institute of Spine and Joint Pathology, NAMS of Ukraine” – is the oldest scientific and treatment establishment in Ukraine, created in 1907.

The staff of the Institute includes 23 Full Doctors of Sciences with 7 Professors among them, and 53 PhDs.

SI “Sytenko Institute for Spine and Joints Pathology of the NAMS of Ukraine” is a head scientific institution dealing with problems of the spine and joints pathology among all institutions of the Academy of Medical Sciences of Ukraine and provides proper co-ordinating work on scientific research and organizing measures in this field.

Privileged research directions of the institution:

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experimental and theoretical investigation of the problems of diagnostics, conceptual foresight of the states of diseases and injuries of the joints and spine (adults and children), complications preventing, working-out of new treatment technologies (including surgical), working-out of the techniques of patients rehabilitation according to the different stages of treatment;

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investigation of the possibilities and usage of surgical treatment of benign and malignant bone tumors with the focus on the organ preserving surgery on spine and extremities;

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working-out of new bioinert implant materials for the plastic repair of vertebral bone defects;

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development of advanced methods of tissue engineering, directed on the restoration of function of loco-motor apparatus, particularly, in the case of injury and disease of spine and joints;

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working-out of new and improvement of existing methods for prevention, diagnostics and treatment of disabling diseases and injuries of spine and joints in children.

2022

Fundamental researches in the theoretical and clinical medicine

To explore etiopathogenesis and sanogenetic role of paravertebral muscles in development lumbar degenerative diseases.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — D.Med.Sc. A.Skidanov

To study the mechanisms of optimization of bone repair depending on the recipient’s age under the conditions of allogeneic bone grafts application in combination with mesenchymal stem cells and biologically active blood plasma factors.

Scietific Director — prof. M.Korzh, D.Med.Sc.

Principle Investigators — MD PhD P. Vorontsov, PhD BioSc. N. Ashukina

Experimental study of bone tissue reaction and biomechanical properties of “implant-bone”system at application of innovative 3D-printed materials made of polilactide acid and trabecular titanium.

Scietific Director — prof. V.Filipenko, D.Med.Sc.

Principle Investigator — MD PhD O.Pidgaiska

Applied researches

Develop a comprehensive approach to treatment of congenital pseudoarthrosis of the tibia and fibula in children.

Scietific Director — prof. S.Khmyzov,D.Med.Sc.

Principle Investigator — Ye.Katsalap

To study the features of functional disorders in the combined pathology of the lumbar spine and hip joint and to develop tactics and requirements for the surgical treatment of these patients.

Scietific Director — prof. M.Korzh, D.Med.Sc.

Principle Investigators — PhD in MedSci K.Popsuishapka, MD PhD O.Pidgaiska

To study the pathophysiological mechanisms of hemodynamic and neurological reactions caused by the type of anesthesia and intraoperative position of the patient’s body during spine surgery.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigators — D.Med.Sc. M.Lyzohub, PhD in MedSci MD PhD I.Kotulsky

Develop tactics of rational spinal fusion for the treatment of patients with vertebral fractures of the thoracic spine.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigators — PhD in MedSci K.Popsuishapka, S.Teslenko

To develop differentiated approaches of surgical treatment of patients with pelvic bone tumors.

Scietific Director — prof. O.Vyrva, D.Med.Sc.

Principle Investigator — MD PhD R.Malyk

Improve methods of surgical treatment of patients with degenerative-dystrophic diseases of the lumbar spine using the latest technologies.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — MD PhD O.Barkov

To study the mechanisms of formation of immobilization contractures and to investigate the influence of low-frequency vibration on the restoration of joint function.

Scietific Director — prof. O.Tyazhelov ,D.Med.Sc.

Principle Investigator — M. Karpisky

Develop a set of medical and organizational measures to improve the system of medical care for victims of road accidents.

Scietific Director — prof. V.Tankut D.Med.Sc.

Principle Investigator — I. Golubeva

2021

Fundamental researches in the theoretical and clinical medicine

To explore etiopathogenesis and sanogenetic role of paravertebral muscles in development lumbar degenerative diseases.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — D.Med.Sc. A.Skidanov

To study the mechanisms of optimization of bone repair depending on the recipient’s age under the conditions of allogeneic bone grafts application in combination with mesenchymal stem cells and biologically active blood plasma factors.

Scietific Director — prof. M.Korzh, D.Med.Sc.

Principle Investigators — MD PhD P. Vorontsov, PhD BioSc. N. Ashukina

Experimental study of bone tissue reaction and biomechanical properties of “implant-bone”system at application of innovative 3D-printed materials made of polilactide acid and trabecular titanium.

Scietific Director — prof.V.Filipenko, D.Med.Sc.

Principle Investigator — MD PhD O.Pidgaiska

Applied researches

To study the main errors and complications of transpedicular fixation in spine surgery and to develop measures for their prevention and treatment.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — MD PhD O.Barkov

To study the biomechanical features of the standing and walking function of a man after hip arthroplasty.

Scietific Director — prof. O.Tyazhelov ,D.Med.Sc.

Principle Investigator — M. Karpisky

To work out the system of organizational arrangements, curative and preventive services, to decrease negative consequences of the traumatic and combat injuries of long bones.

Scietific Director — prof. M.Korzh,D.Med.Sc.

Principle Investigator — MD PhD K.Romanenko

Develop a comprehensive approach to treatment of congenital pseudoarthrosis of the tibia and fibula in children.

Scietific Director — prof. S.Khmyzov,D.Med.Sc.

Principle Investigator — Ye.Katsalap

To study the features of functional disorders in the combined pathology of the lumbar spine and hip joint and to develop tactics and requirements for the surgical treatment of these patients.

Scietific Director — prof. M.Korzh, D.Med.Sc.

Principle Investigators — PhD in MedSci K.Popsuishapka, MD PhD O.Pidgaiska

To explore etiopathogenesis and sanogenetic role of paravertebral muscles in development lumbar degenerative diseases.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — D.Med.Sc. A.Skidanov

To study the pathophysiological mechanisms of hemodynamic and neurological reactions caused by the type of anesthesia and intraoperative position of the patient’s body during spine surgery.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigators — D.Med.Sc. M.Lyzohub, PhD in MedSci MD PhD I.Kotulsky

Develop tactics of rational spinal fusion for the treatment of patients with vertebral fractures of the thoracic spine.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigators — PhD in MedSci K.Popsuishapka, S.Teslenko

To develop differentiated approaches of surgical treatment of patients with pelvic bone tumors.

Scietific Director — prof. O.Vyrva, D.Med.Sc.

Principle Investigator — MD PhD R.Malyk

2020

Fundamental researches in the theoretical and clinical medicine

To explore etiopathogenesis and sanogenetic role of paravertebral muscles in development lumbar degenerative diseases.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — D.Med.Sc. A.Skidanov

To study the mechanisms of optimization of bone repair depending on the recipient’s age under the conditions of allogeneic bone grafts application in combination with mesenchymal stem cells and biologically active blood plasma factors.

Scietific Director — prof. M.Korzh, D.Med.Sc.

Principle Investigators — MD PhD P. Vorontsov, PhD BioSc. N. Ashukina

Experimental study of bone tissue reaction and biomechanical properties of “implant-bone”system at application of innovative 3D-printed materials made of polilactide acid and trabecular titanium.

Scietific Director — prof. V.Filipenko, D.Med.Sc.

Principle Investigator — MD PhD O.Pidgaiska

Applied researches

Develop a concept of treatment of traumatic and humidified burst bodies of the thoracal and lumbar spine.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — PhD in MedSci K.Popsuishapka

Improve the diagnosis and surgical treatment of patients with hematopoietic and metastatic lesions of thoracic and lumbar spine.

Scietific Director — D.Med.Sc. V.Kutsenko

Principle Investigator — MD PhD A.Popov

To investigate the causes of development and improve the methods of prevention and treatment of contracture of the knee joints in gonarthrosis, as consequences of traumatic injuries and after total knee arthroplasty.

Scietific Director — prof.V.Filipenko, D.Med.Sc.

Principle Investigator — MD PhD O.Tankut

Develop methods bioreсonstrution defects of long bones and joints in the surgical treatment of bone tumors.

Scietific Director — prof. O.Vyrva, D.Med.Sc.

Principle Investigator — MD PhD Ya.Holovina

To study the main errors and complications of transpedicular fixation in spine surgery and to develop measures for their prevention and treatment.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — MD PhD O.Barkov

To study the biomechanical features of the standing and walking function of a man after hip arthroplasty.

Scietific Director — prof. O.Tyazhelov ,D.Med.Sc.

Principle Investigator — M. Karpisky

To work out the system of organizational arrangements, curative and preventive services, to decrease negative consequences of the traumatic and combat injuries of long bones.

Scietific Director — prof. M.Korzh,D.Med.Sc.

Principle Investigator — MD PhD K.Romanenko

Develop a comprehensive approach to treatment of congenital pseudoarthrosis of the tibia and fibula in children.

Scietific Director — prof. S.Khmyzov,D.Med.Sc.

Principle Investigator — Ye.Katsalap

2019

Fundamental researches in the theoretical and clinical medicine

To explore common links in the mechanism of pathogenesis of osteoporosis, osteoarthrosos and spine osteochondrosis for substantiation of approaches to improve the efficiency of diagnosis, prevention and treatment.

Scietific Director — prof. M.Korzh , D.Med.Sc.

Principle Investigators — prof. V.Filipenko, D.Med.Sc., PhD BioSc. N. Ashukina

To investigate the pathogenetic mehanisms of juvenile osteochondropathic kyphosis formation (Scheueremann’s disease).

Scietific Director — prof. M.Korzh, D.Med.Sc.

Principle Investigators — MD PhD I.Kotulsky, prof. S.Khmyzov, D.Med.Sc

To study the reparative properties of bioengineered structures on the basis of bone allografts and xenografts that are saturated with stem cells and growth factors.

Scietific Director — prof. M.Korzh, D.Med.Sc.

Principle Investigator — MD PhD P. Vorontsov

Applied researches

Develop a concept of treatment of traumatic and humidified burst bodies of the thoracal and lumbar spine.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — PhD in MedSci K.Popsuishapka

Improve the diagnosis and surgical treatment of patients with hematopoietic and metastatic lesions of thoracic and lumbar spine.

Scietific Director — D.Med.Sc. V.Kutsenko

Principle Investigator — MD PhD A.Popov

To investigate the causes of development and improve the methods of prevention and treatment of contracture of the knee joints in gonarthrosis, as consequences of traumatic injuries and after total knee arthroplasty.

Scietific Director — prof.V.Filipenko, D.Med.Sc.

Principle Investigator — MD PhD O.Tankut

Develop methods bioreсonstrution defects of long bones and joints in the surgical treatment of bone tumors.

Scietific Director — prof. O.Vyrva, D.Med.Sc.

Principle Investigator — MD PhD Ya.Holovina

To study the main errors and complications of transpedicular fixation in spine surgery and to develop measures for their prevention and treatment.

Scietific Director — prof. V.Radchenko, D.Med.Sc.

Principle Investigator — MD PhD O.Barkov

To study the biomechanical features of the standing and walking function of a man after hip arthroplasty.

Scietific Director — prof. O.Tyazhelov ,D.Med.Sc.

Principle Investigator — M. Karpisky

To work out the system of organizational arrangements, curative and preventive services, to decrease negative consequences of the traumatic and combat injuries of long bones.

Scietific Director — prof. M.Korzh,D.Med.Sc.

Principle Investigator — MD PhD K.Romanenko

Scientific research works for 2012 year.

Scientific research works for 2010 year.

1.	0108U 001072	To investigate reparative osteogenesis and changes in the tissues of injured segment in the conditions of multiplane posttraumatic deformity of extremity (experimental-clinical investigation)
2.	0108U 001073	To research the monoaminergic and cholinergic effects in the cases of pain syndroms with different origin in locomotor system (08.01-10.12)
3.	0110U 00____	To study mechanisms of development of lumbar degenerate stenosis (10.01-12.12)
4.	0110U 00____	To study the state of adjacent motor vertebral segments after fusion (10.01-12.12)
5.	0108U 001074	To treat new methods of osteosynthesis with carbon implants for metaphyseal and metadiaphyseal fractures of long bones for elder people (08.01-10.12)
6.	0108U 000391	To study the influens of complex using low level infra-red radiation and medical drugs on ostearthrosis progression (08.01-10.12)
7.	0108U 1076	To develop new methods of endoprosthetic replacement of bones and joints defects in the treatment of bone tumors of the upper limbs (08.01-10.12)
8.	0109U 002015	To study mechanisms of progressing lumbar spondylolistesis and to develop criterions of forecasting of its course and consequences (09.01-11.12)
9.	0109U 002014	Adult scoliosis diagnostic and treatment optimization
10.	0109U 002016	To develop application technology of hip endoprosthesis with a singl-crystal corundum (09.01-11.12)
11.	0110U 00____	To explore intercommunication between violations of bone and cartilaginous tissues metabolism and system of haemostase at patients with the different stages of large joints osteoarthrosis for warning of the hypercoagulabilitys states development (10.01-12.12)
12.	0110U 00____	To study the condition and dynamics of disability connected with degenerative spine and elaborate a comprehensive complex of activites in order to prophylaxis of disability (10.01-12.12)
13.	0109U	Ground and development the methods of diagnostic and the prevention surgical treatment of spastic hip joint instability in children with cerebral palsy (09.01-11.12)
14.		Bactericidal coverings for orthopedy and traumatology (08.02-10.02)

Scientific research works for 2009 year.

1.	0107U 000106	To study the mechanisms of development and age pecularities of degenerative diseases of the spine (07.01 – 09.12)
2.	0107U 000107	To study experimentally the structure and mechanical properties of the adjacent spine segments in different variants of biomaterials implantation into the vertebra (07.01 – 09.12)
3.	0108U 001072	To investigate reparative osteogenesis and changes in the tissues of injured segment in the conditions of multiplane posttraumatic deformity of extremity (experimental-clinical investigation)(08.01-10.12)
4.	0108U 001073	To research the monoaminergic and cholinergic effects in the cases of pain syndroms with different origin in locomotor system (08.01-10.12)
5.	0107U 000109	To study diagnostic significance of glycoproteins and glycosaminglycanes metabolic indeces fior the flow of large joints osteoartrosis (07.01-09.12)
6.	0107U 000111	To study a degree and criteria of disability in the diseases of major joints and develop complex mesurements for its prevention. (07.01-09.12)
7.	0108U 001074	To treat new methods of osteosynthesis with carbon implants for metaphyseal and metadiaphyseal fractures of long bones for elder people (08.01-10.12)
8.	0108U 000391	To study the influens of complex using low level infra-red radiation and medical drugs on ostearthrosis progression (08.01-10.12)
9.	0108U 1076	To develop new methods of endoprosthetic replacement of bones and joints defects in the treatment of bone tumors of the upper limbs (08.01-10.12)
10.	0109U 002015	To study mechanisms of progressing lumbar spondylolistesis and to develop criterions of forecasting of its course and consequences (09.01-11.12)
11.	0109U 002014	Adult scoliosis diagnostic and treatment optimization (09.01-11.12)
12.	0109U 002016	To develop application technology of hip endoprosthesis with a singl-crystal corundum (09.01-11.12)
13.	0107U 000112	To study the perculiarities of the postoperative hip joints development in children with displastic joints pathology, to develop and justify new methods of surgical intervention and modify the ones already existed (07.01-09.12)
14.	0109U	Ground and development the methods of diagnostic and the prevention surgical treatment of spastic hip joint instability in children with cerebral palsy (09.01-11.12)
15.		Bactericidal coverings for orthopedy and traumatology (08.02-10.02)

Scientific research works for 2008 year.

1.		Development and improvement of complex of diagnostic and treatment events of the cervical spine deformations. (2006-2008)
2.		To develop a system of the surgical treatment of juvenile scoliosis. (2006-2008)
3.		To study experimentally the structure and mechanical properties of the adjacent spine segments in different variants of biomaterials implantation into the vertebra. 2007-2009
4.		To study the mechanisms of development and age pecularities of degenerative diseases of the spine. 2007-2009
5.		To develop new methods of the total hip joint endoprosthetics in the acetabulum defects. 2007-2008
6.		To study diagnostic significance of glycoproteins and glycosaminglycanes metabolic indeces fior the flow of large joints osteoartrosis. 2007-2009
7.		To develop methods of surgical correction of the knee joint deformation on the grounds of topographical studies of the binite-element model voltages. 2007-2009
8.		To study a degree and criteria of disability in the diseases of major joints and develop complex mesurements for its prevention. 2007-2009
9.		To study the perculiarities of the postoperative hip joints development in children with displastic joints pathology, to develop and justify new methods of surgical intervention and modify the ones already existed. 2007-2009
10.		To investigate reparative osteogenesis and changes in the tissues of injured segment in the conditions of multiplane posttraumatic deformity of extremity (experimental-clinical investigation)2008-2010
11.		To research the monoaminergic and cholinergic effects in the cases of pain syndroms with different origin in locomotor system 2008-2010
12.		To treat new methods of osteosynthesis with carbon implants for metaphyseal and metadiaphyseal fractures of long bones for elder people 2008-2010
13.		To study the influens of complex using low level infra-red radiation and medical drugs on ostearthrosis progression. 2008-2010
14.		To develop new methods of endoprosthetic replacement of bones and joints defects in the treatment of bone tumors of the upper limbs. 2008-2010

1.		To study the bone regeneration at the traumatic damages at endocrine osteoporosis. (2005-2007).
2.		To research pathogenesis and to improve methods diagnostics and conservative treatment for avascular necrosis of the femoral head in adults. (2005-2007).
3.		Research osteointegration processes at plastics of bone defects by calcium phosphate ceramics of different structure and composition. (2004-2006).
4.		Develop the grafts on the base of connective tissue cells grown on the biodegradable matrixes for optimization of the repair process of the intervertebral disc. (2004-2006).
5.		Development of new and improvement of existing methods of operative management of spinal injuries and their consequents. (2003-2005).
6.		Investigate the change made by spinal orthosis in scoliotic deformation in children and adolescent for improvement of medical effect. (2003-2005).
7.		Study of genesis of degenerative and dysplastic deformities of lumbar spine in adult, work out methods of early diagnosis, prognosis and surgical treatment. (2004-2006).
8.		To develop new high technological methods of osteosynthesis and substitution of bone defects in elderly patients with carbon and ceramic implants. (2004-2006).
9.		To study the disability condition connected with spine diseases and elaborate a comprehensive complex of activities in order to reduce the number of disability value. (2004-2006).
10.		To research of results of individual endoprosthetics of long bone and joint postresection defects in the system of complex treatment of bone tumors. (2005-2007).
11.		To study of changes of aged patients on osteoartrosis clinical course in application of pelotherapy. (2005-2007).
12.		To develop technology of early diagnostics, treatment and prophylaxis of dysplastic spine and joints diseases resulting in invalidism in young age. (2003-2006).
13.		Design, making and clinical using of new native artificial hip joint with sapphire-sapphire friction pair. (2003-2006).
14.	1913	Development and clinical approval of sapphire-metallic hip joint endoprothesis. (2002-2005).
15.	3174	Development of new types of intraosseous fixative devices with a removable and biodegradable coating. (2004-2007).

1.		To study mechanisms of osteopenia and osteoporosis development in the conditions of traumatic injuries of long bones
2.		To research features of pathogenesis in circadian rtythms of transitory low back pain
3.		To develop a system of limb-salvage surgery in patients with malignant tumors of long bones.
4.		Features of formation of a trajectory of moving of the general centre of weights of the person in the course of support of a vertical pose for diagnostics of infringements of function of oporno-impellent system
5.		To study the bone rebuilding in exteriorization zone of titanic implants under the influence of ultrasound
6.		Ground and development the methods of diagnostic and the surgical treatment of congenital anomaly of hand and forearm in children.