Sytenko Institute of Spine and Joint Pathology, National Academy of Medical Science
80 Pushkinska Street, Kharkiv, 61024, Ukraine
Phone: +380(57)725-14-00
https://sytenko.org.ua
Phone: +380951983283 (Ukraine)
Email: nlizogub@gmail.com

QUALIFICATIONS

2021

Doctor of Medical Science (DSc)
Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

2018

Specialist, Pediatric Anaesthesiology
Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine

2008

Doctor of Philosophy (PhD)
Donetsk National Medical University, Donetsk, Ukraine

2002

Specialist, Anaesthesiology
Department of Anaesthesiology and Intensive Care, Kharkiv National Medical University, Kharkiv, Ukraine

2000

Doctor of Medicine (MD)
Kharkiv National Medical University, Kharkiv, Ukraine

ACADEMIC APPOINTMENTS

2021 – present

Professor, Department of Anaesthesiology, Intensive Therapy and Paediatric Anaesthesiology, Kharkiv National Medical University, Kharkiv, Ukraine
• Teaching 30%, Research 20%, Clinical 50%

2004 – 2021

Associate Professor, Department of Critical Care Medicine, Anaesthesiology, and Intensive Care, Kharkiv National Medical University, Kharkiv, Ukraine

PROFESSIONAL APPOINTMENTS

2023 – now

Medical Director
Consultant Anaesthesiologist, Head of the Department
Department of Anaesthesiology and Intensive Care, Sitenko Institute of Spine and Joint Pathology, National Academy of Medical Sciences, Kharkiv, Ukraine

2011 – 2023

Organize and provide quality anaesthetic and intensive care support in the setting of tertiary level medical facility, serving adult and paediatric population with orthopaedic pathology and trauma, including major bone oncology surgery, deformity correction surgery in children and adults, arthroplasty and arthroscopy, musculoskeletal trauma.

2004 – 2011

Consultant Anaesthesiologist
Intensive Care Unit, Meshchaninov’s Kharkiv Emergency Medical Care Hospital, Kharkiv, Ukraine

Provided quality intensive care support in the ICU setting of secondary level medical facility, serving adult and paediatric population with severe traumatic brain injury, stroke, asthma, sepsis, pneumonia, acute hepatic failure, acute kidney injury, exogenous intoxication, gastrointestinal bleeding, asphyxia, etc.

2000 – 2004

Resident Doctor, Anaesthesiology
Department of Anaesthesiology, Meshchaninov’s Kharkiv Emergency Medical Care Hospital, Kharkiv, Ukraine

Anaesthesiology trainee. Provided quality care to adult and paediatric patients in the secondary level medical facility setting; rotations: anaesthesiology – 12 months, intensive care – 12 months, theoretical and simulation studying – 20 months

PUBLICATIONS (peer-reviewed original manuscripts)

1. Lyzohub K.I., Lyzohub, M.V. Systemic and cerebral hemodynamic changes in patients undergoing shoulder arthroscopy in the beach chair position. Orthopaedics, Traumatology and Prosthetics, 2024;2024(1):38–42. http://dx.doi.org/10.15674/0030-59872024138-42
2. Kravchun, P.G., Korzh, M.O., Leontieva, F.S., Lyzohub M.V., Dielievska, V.Y. Resolving Discrepancies in Forward and Reverse ABO Blood Group Typing. Scripta Medica (Banja Luka), 2023;54(4):425–437. https://doi.org/10.5937/scriptamed54-45572
3. Korsunov, V., Bocharova, T.V., Skoryk, V.S., Lyzohub M, Lyzohub, K.I., Lisiienko, Y.O. Lung morphology changes in patients with COVID-induced acute respiratory distress syndrome depending on the respiratory therapy options. Emergency Medicine (Ukraine), 2023;19(4):225–233. https://doi.org/10.22141/2224-0586.19.4.2023.1589
4. Lyzogub K, Nikonov V, Lyzohub M, Kursov S, Feskov F, Yakovenko S. Postoperative cognitive dysfunctions and operating position. EMERGENCY MEDICINE, 2022;18(3): 44–47. https://doi.org/10.22141/2224-0586.18.3.2022.1490 (UKR)
5. Nikonov VV, Lizogub KI, Lizogub MV. Influence of premedication and anaesthesia on agitation and postoperative cognitive function during lumbar spine surgery. EMERGENCY MEDICINE, 2021; #17(3):25-29. DOI: https://doi.org/10.22141/2224-0586.8.103.2019.192379
6. Nikonov VV, Lizogub KI, Lizogub MV. Influence of premedication and anaesthesia on agitation and postoperative cognitive function during lumbar spine surgery. EMERGENCY MEDICINE, 2021; #17(3):25-29. DOI: https://doi.org/10.22141/2224-0586.8.103.2019.192379 (UKR)
7. Lyzohub M, Kotulskiy I, Lyzohub K, Moskalenko N, Pishchik V. Type of anesthesia for lumbar spine surgery in prone position. ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS, 2020; #4(617):37–41. https://doi.org/10.15674/0030-59872019437-41. (UKR)
8. Lyzohub M, Georgiyants M, Lyzohub K, Volkova Ju, Dmitriiev D, Dmitriiev K. Influence of anesthesia type on intraocular pressure during spine surgery in prone position. Wiadomosci lekarskie. 2020; 1:104-107 PMID: 32124817
9. Lyzohub M, Georgiyants M, Vysotska O, Porvan A, Lyzohub K. Cardiovascular changes in human body after changing position supine to prone. Georgian Med News. 2019; 289:91-94. PMID: 31215886
10. Lyzohub M, Georgiyants M, Lyzohub K. Evaluation of pain syndrome and efficiency of pain management in lumbar spine surgery. Eureka: Health Sciences. 2019; 6:29-34. DOI: https://doi.org/10.21303/2504-5679.2019.001068
11. Lyzohub M. Hemodynamics in different types of anesthesia depending on the initial blood circulation regime during spine surgery in prone position. Ukrainian Journal of Medicine, Biology and Sport. 2019;4/5(21): 149-153. DOI: https://doi.org/10.26693/jmbs04.05.149
12. Lyzohub M, Kotulskiy I, Moskalenko N, Pishchik V. Dynamic of functional parameters of cardio-vascular system in patients with vertebrogenic pathology after body position changes. ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS, 2019; #1:25–30. https://doi.org/10.15674/0030-59872019125-30 (UKR)
13. Lyzohub M, Georgiyants M, Lyzohub K. Influence of anesthesia type on blood loss during lumbar spine surgery. EMERGENCY MEDICINE, 2019; #3.98, 80–84. https://doi.org/10.22141/2224-0586.3.98.2019.165483 (UKR)
14. Lizogub MV, Georgiyants MA, Lizogub KI. Influence of anesthesia type on blood loss during lumbar spine surgery. EMERGENCY MEDICINE, 2019; #3(98):80-84. DOI: https://doi.org/10.22141/2224-0586.3.98.2019.165483 (UKR)
15. Lizogub MV, Georgiyants MA, Lizogub KI, Khmizov AI. Pain syndrome and pain management after lumbar spine surgery PAIN, ANAESTHESIA & INTENSIVE CARE, 2019; #3:23-26. DOI: https://doi.org/10.25284/2519-2078.3(88).2019.177391 (UKR)
16. Lyzohub MV, Leontieva FS, Lyzohub KI. Dynamics of Biochemical Markers of Operational Stress in the Blood of Patients with Surgical Interventions on the Lumbar Spine Depending on the Type of Anesthesia. Ukrainian Journal of Medicine, Biology and Sport. 2018;3/5(14):105-109. DOI: https://doi.org/10.26693/jmbs03.05.105 (UKR)
17. Lyzogub M, Leontyeva F, Skidanov A, Piontkovsky V. Study of the cytokine profile at surgeries on the lumbar spine: Influence of the method of anesthesia ORTHOPAEDICS, TRAUMATOLOGY AND PROSTHETICS, 2018; #2(611):28-32. https://doi.org/10.15674/0030-59872018228-32 (UKR)
18. Lizogub MV, Georgiyants MA, Lizogub KI. Influence of premedication and anaesthesia on agitation and postoperative cognitive function during lumbar spine surgery. EMERGENCY MEDICINE, 2019;8(103):106-110. DOI: https://doi.org/10.22141/2224-0586.8.103.2019.192379 (UKR)
19. Lyzohub M, Georgiyants M, lyzohub K, Khmyzov A. Pain syndrome and pain management after lumbar spine surgery. PAIN, ANAESTHESIA & INTENSIVE CARE, 2018;3(88):23–26. https://doi.org/10.25284/2519-2078.3(88).2019.177391 (UKR)
20. Lyzohub M. Dynamics of Cortisol-Insulin Index and Individual Insulin Resistance in Patients after Surgery in the Lumber Spine. Ukrainian Journal of Medicine, Biology and Sport. 2018; 3/7(16):117-121. DOI: https://doi.org/10.26693/jmbs03.07.117 (UKR)
21. Lyzohub M, Georgiyants M. Spinal anaesthesia for spine surgery in prone position PAIN, ANAESTHESIA & INTENSIVE CARE, 2018;2(83):74–78. https://doi.org/10.25284/2519-2078.2(83).2018.135798 (UKR)
22. Lyzohub M. Intraocular pressure investigation during lumbar spine surgery in prone position. ScienceRise: Medical Science, 2017; #11(19):28–30. https://doi.org/10.15587/2519-4798.2017.116416 (UKR)
23. Lyzogub K, Kursov S, Lyzogub M. Using of modern patterns of intraoperative fluid resuscitation in orthopedic oncology. ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS, 2017;#4;34–39. https://doi.org/10.15674/0030-59872017434-39 (UKR)
24. Kursov SV, Lizogub KI, Lizogub MV. Analysis of the results of the study of central hemodynamics and peripheral capillary blood flow at different modes of intraoperative fluid management. EMERGENCY MEDICINE, № 7 (86), 2017:50-58. DOI: https://doi.org/10.22141/2224-0586.7.86.2017.116880 (UKR)
25. Lyzohub M. Postural hemodynamic changes after turning to prone position. ScienceRise:Medical Science, 2015;Vol.3.No.4(8):71-74. https://doi.org/10.15587/2313-8416.2015.39269 (UKR)
26. Lyzohub M. Deliberate hypotension for spine surgery in prone position. ScienceRise: Medical Science. 2015;Vol.2#4(7):73-76. DOI: https://doi.org/10.15587/2313-8416.2015.38140 (UKR)

PUBLICATIONS (conference abstracts)

27. Lyzohub M, Rakhmail M, Zgola I, Orlov G, Lyzohub K. Hemodynamic changes during general anesthesia in prone position. EJA. 2015;32(suppl.53)
28. Volkova Y, Lyzogub M. The influence of apoptosis on the outcome of multiple trauma in the elderly: 18AP1-9. EJA, 2014;31:263

RESEARCH EXPERIENCE

2016 – 2020

Anesthesiologic approach for lumbar spine surgery in prone position: rationale of choosing an anesthesia method. (DSc thesis)
The number of degenerative lumbar spine diseases is increasing progressively. Lumbar spine surgery has been routinely performed under general anesthesia, but spinal anesthesia may be safe and effective alternative. Among the advantages of spinal anesthesia lower blood loss and length of stay, reducing of postoperative nausea and vomiting (PONV) and cost effect are described. Unfortunately, there are no guidelines for choosing of anesthesia type because such operations have several peculiarities regarding prone position, deliberate hypotension, pain syndrome and specific complications, like postoperative visual loss. The aim of the study was to improve the results of anesthesia management for elective lumbar spine surgery due to degenerative diseases on the base of studying of hemodynamics, pain syndrome, cognitive functions, biochemical stress markers, intraocular pressure and spinal anaesthetic distribution in prone position.
254 ASA I-III patients aged 18–75-year-old were enrolled into prospective study. Patients were divided randomly into 2 groups. Patients of group SA were operated under spinal anesthesia; patents of group TIVA were operated under intravenous propofol/fentanyl anesthesia. Additionally, patients were divided into subgroups StA (obtained standard postoperative analgesia) and MMA (multimodal postoperative analgesia). It was shown that turning of the patient into prone position leads to statistically significant hemodynamic changes. Peripheral vascular resistance increased by 13,4 ± 3,4 % and stroke volume index (SVI) decreased by 14,8 ± 3,5 %. These changes were mostly dependent from body mass index (BMI). In patients with normal BMI SVI decreased by 11,0 ± 3,0 % 5 min after turning and in 20 min it returned to normal range. In obese patients SVI decreased by 18,3 ± 3,9 % after turning and it did not return to normal range in 20 min. We compared preoperative and intraoperative hemodynamic changes and the mathematical model of prognostic index of hemodynamic instability (PIHI) we produced. In patients with PIHI ≥ 0,5 there is high risk of severe hypotension after turning into prone position in patients under SA. For such patients it is better to choose TIVA. The exception are patients older than 60-year-old. In this group of patients SA is more hemodynamically stable regardless the level of PIHI. During surgery deliberate hypotension was induced with level of mean blood pressure 60-80 mm Hg. According to our data this level was effective and safe as it had no influence on postoperative neurological recovery and function of kidneys. We performed a series of CT myelograms to assess the distribution of hyperbaric solution in prone position. We revealed that typically the biggest amount of hyperbaric solution is located at the level LI-LII with highest level at ThXI-ThXII. Using of isobaric bupivacaine is suitable for surgery lower than LIII and duration 2 hours and less and allows to start surgery faster as the patient can position himself on his own. Hyperbaric solution allows to increase the level to LI and duration of surgery up to 3 hours. Exposition in supine position should be 5 min. Intraocular pressure increased in prone position in anesthetized and non-anesthetized patients. The most significant changes were found in patients of TIVA group in the dependent eye if the head was rotated 45°. Intraocular pressure of non-anesthetized patients was similar to those of group SA. Among biochemical markers of stress significant changes were found in levels of cortisol and IL-6. Cortisol level was higher in TIVA group on the end of surgery than in SA group. Level of IL-6 was found to be higher 30 min after incision in TIVA group comparing with SA group. When we studied pain syndrome, we found that neuropathic component was present in 53,9 ± 4,9 % of patients. In patients with neuropathic component pain syndrome was significantly more severe before surgery and on the 3rd day after surgery. We used our algorithm of multimodal perioperative pain management that included pregabalin, paracetamol, parecoxib and morphine (optionally). This algorithm allowed to decrease requirements for morphine and incidence of PONV and dizziness. Anesthesia type had no influence on postoperative cognitive function. Significant decreasing of the attention was found in patients who received standard analgesia regimen with higher morphine dose instead of MMA. On the base of our investigation the algorithm of choosing of anesthesia type was produced, that included PIHI, level of surgery, estimated time of surgery, level of psychological stress. We applied the algorithm to 30 patients and we found significant difference, comparing to 30 patients with random choosing, in length of stay 7,1 ± 1,4 vs 10,7 ± 1,1 days (р < 0,05), time in intensive care ward 0,3 ± 0,5 vs 1,4 ± 0,9 days (р < 0,05), sympathomimetic requirements 5,1 ± 1,8 % vs 9,8 ± 1,5 % (р < 0,05), time of mobilization on postoperative day 1 18,1 ± 6,2 vs 7,4 ± 3,8 min.

2005 – 2008

Clinical and immunochemical assessment of the brain-protective effect in severe traumatic brain injury. (PhD thesis)
The study is dedicated to the problem of diagnosing of the blood-brain barrier damage and to the intensive therapy of severe traumatic brain injury (TBI). We analysed the results of treatment of 191 patients with severe TBI and we showed the epidemiological and clinical features of this type of trauma. We worked up the ELISA for glial fibrillary acid protein and neuronspecific enolase and we examined their blood concentrations in 45 healthy donors and 46 patients with severe TBI in dynamics. We demonstrated the brake of the blood-brain barrier and elimination of the neuronspecific proteins to the blood in an acute phase of severe TBI. We showed the role of the neuronspecific proteins in diagnosing of severe TBI. We improved the algorithm of severe TBI treatment by adding of L-lysin aescinat and 2-aethyl-6-methyl-3-hydroxypiridin to intensive therapy. With the help of our algorithm, we reduced the mortality, the number of days in coma, the number of days with pulmonary ventilation and we reduced the level of neuronspecific proteins in blood in patients with severe TBI.

TEACHING EXPERIENCE

1. Teaching for medical students on course Anaesthesiology and Intensive Therapy.
2. Teaching postgraduate doctors in residency on Anaesthesiology and Intensive Therapy.
3. Masterclasses on Ultrasound Guided Regional Anesthesia for anaesthesiologists.

INTERNATIONAL CONFERENCES AND TRAINING

Open Medical Institute Salzburg Seminar: Anaesthesiology, 2008.
Open Medical Institute Salzburg Seminar: Spinal Surgery, 2012
Open Medical Institute Observerships in Anaesthesiology, Vienna, 2014
Open Medical Institute Observerships in Anaesthesiology, Vienna, 2018
European Society of Anaesthesiology Euroanesthesia 2014, Stockholm, Sweden
European Society of Anaesthesiology Euroanesthesia 2015, Berlin, Germany
ATLS Course for Doctors, Tartu, Estonia, 2016
European Society of Anaesthesiology Euroanesthesia 2017, Copenhagen,
International Symposium of Intensive Care and Emergency Medicine 2019, Brussels, Belgium

MANAGERIAL EXPERIENCE

Chief of the Department of Anaesthesiology and Intensive Therapy since 2011

PROFESSIONAL EXAMINATIONS

2018

Specialty Examination in Paediatric Anaesthesiology and Paediatric Intensive
Care and Emergency Medicine. Kharkiv Medical Academy of Postgraduate
Education. Ministry of Health of Ukraine

2002

Specialty Examination in Anaesthesiology. Kharkiv National Medical University.
Ministry of Health of Ukraine

2000

State Final Medical Examinations. Kharkiv National Medical University. Ministry
of Health of Ukraine

AWARDS

From National Academy of Medical Science of Ukraine – 2017

MEMBERSHIPS AND PROFESSIONAL REGISTRATIONS
Ukrainian Medical Council, since 2000
Association of Anaesthesiologists of Ukraine, since 2002

LANGUAGES

English FCE (B2)
Ukrainian Native